Prediction Model Validation: Normal Human Pigmentation Variation
نویسندگان
چکیده
منابع مشابه
The genetic architecture of normal variation in human pigmentation: an evolutionary perspective and model.
Skin pigmentation varies substantially across human populations in a manner largely coincident with ultraviolet radiation intensity. This observation suggests that natural selection in response to sunlight is a major force in accounting for pigmentation variability. We review recent progress in identifying the genes controlling this variation with a particular focus on the trait's evolutionary ...
متن کاملWorldwide polymorphism at the MC1R locus and normal pigmentation variation in humans.
While there have been many advances in our understanding of the genetics of pathological skin pigmentation in humans, our knowledge about what determines variation in normal skin color is still incomplete. Variation in one gene, melanocortin 1 receptor (MC1R), has been associated with red hair and fair skin in Europeans. However, this gene might also play an important role in shaping pigmentati...
متن کاملNormal Human Variation: Refocussing the Enhancement Debate
This article draws attention to several common mistakes in thinking about biomedical enhancement, mistakes that are made even by some supporters of enhancement. We illustrate these mistakes by examining objections that John Harris has recently raised against the use of pharmacological interventions to directly modulate moral decision-making. We then apply these lessons to other influential figu...
متن کاملPigmentation in Human Skin
Topica! tyrosine has been proposed as a tanning accelerator because tyrosine is a precursor of melanin. We tested formulations containing O, 1, and 2% L-tyrosine topically on 14 individuals daily for 28 days. Percutaneous absorption using "C tyrosine was 1.23% in 24 hr. No enhanced pigmentation was clinically evident in any of the subjects. In this study, we were unable to demonstrate that topi...
متن کاملHuman pigmentation variation: evolution, genetic basis, and implications for public health.
Pigmentation, which is primarily determined by the amount, the type, and the distribution of melanin, shows a remarkable diversity in human populations, and in this sense, it is an atypical trait. Numerous genetic studies have indicated that the average proportion of genetic variation due to differences among major continental groups is just 10-15% of the total genetic variation. In contrast, s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Forensic Research
سال: 2011
ISSN: 2157-7145
DOI: 10.4172/2157-7145.1000139